Results
| PMID | 28322860 |
| Gene Name | IL37 |
| Condition | Endometriosis |
| Association |
Associated |
| Sex | Female |
| Infertility type | Female infertility |
| Other associated phenotypes |
Endometriosis |
|
Immunol Lett. 2017 May;185:52-55. doi: 10.1016/j.imlet.2017.03.012. Epub 2017 Mar Kaabachi, Wajih| Kacem, Olfa| Belhaj, Rafik| Hamzaoui, Agnes| Hamzaoui, Kamel Unit Research 12SP15 "Homeostasis and Cell Dysfunction", A. Mami Hospital, Pavillon B, Ariana, Tunisia; Universite de Tunis El Manar, Faculty of Medicine of Tunis, Department of Basic Sciences, Tunis, Tunisia.| Unit Research 12SP15 "Homeostasis and Cel Interleukin-37 (IL-37) has been identified as a novel anti-inflammatory cytokine. The present study aimed to evaluate the expression of IL-37 in serum and in peritoneal fluid to determine its clinical significance in endometriosis. Enzyme-linked immunosorbent assay (ELISA) was performed to examine serum IL-37 levels in patients with endometriosis and healthy controls. Peritoneal fluid IL-37 mRNA and NFkappaB expression were quantified by real-time reverse transcription polymerase chain reaction assays. The association of IL-37 levels with clinical factors and prognosis of endometriosis was analysed. We found that IL-37 levels in PF and in serum were significantly higher in patients with endometriosis compared to women without endometriosis (P=0.0005). IL-37 levels were highly expressed in PF [132.38+/-34.62pg/mL; P<0.0001] than in serum [74.10+/-13.49pg/mL] in endometriosis patients. IL-37 mRNA expression contrasted with NFkappaB mRNA expression in PF from patients with endometriosis. A significant inverse correlation was observed between IL-37 mRNA and NFkappaB mRNA expression. IL-37 expression correlates with endometriosis severity. The affected NFkappaB mRNA expression in endometriosis contributed the to exhibited increase of IL-37. The increased levels of IL-37 may dampen NFkappaB activation in endometriosis patients. Mesh Terms: Adult| Ascitic Fluid/*immunology| Endometriosis/*immunology| Enzyme-Linked Immunosorbent Assay| Female| Humans| Interleukin-1/*blood/genetics| NF-kappa B/genetics/metabolism| RNA, Messenger/analysis| Young Adult|DA 2018/01/24 06:00 |
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